Modeling the Spatial Spread of Chagas Disease

Bull Math Biol. 2019 Jun;81(6):1687-1730. doi: 10.1007/s11538-019-00581-5. Epub 2019 Feb 25.

Abstract

The aim of this work is to understand the spatial spread of Chagas disease, which is primarily transmitted by triatomines. We propose a mathematical model using a system of partial differential reaction-diffusion equations to study and describe the spread of this disease in the human population. We consider the respective subclasses of infected and uninfected individuals within the human and triatomine populations. The dynamics of the infected human subpopulation considers two disease phases: acute and chronic. The human population is considered to be homogeneously distributed across a space to describe the local propagation of Chagas disease by triatomines during a short epidemic period. We determine the basic reproduction number that allows us to assess Chagas disease control measures, and we determine the speed of disease propagation by using traveling wave solutions for our model.

Keywords: Chagas disease; Reaction–diffusion equation; Traveling waves; Triatomines; Wave speed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basic Reproduction Number / statistics & numerical data
  • Chagas Disease / epidemiology
  • Chagas Disease / parasitology
  • Chagas Disease / transmission*
  • Computer Simulation
  • Epidemics / prevention & control
  • Epidemics / statistics & numerical data
  • Host-Parasite Interactions
  • Humans
  • Insect Vectors / parasitology
  • Mathematical Concepts
  • Models, Biological*
  • Spatio-Temporal Analysis
  • Triatominae / parasitology
  • Trypanosoma cruzi