Abstract
An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a factor. All three factors, i.e., the LDGF from MOLT-4f, CCRF-CEM, and CCRF-HSB-2 are similar to each other both in biological activity and in physicochemical characteristics. In addition to their autocrine activity, these LDGFs stimulate the growth of other malignant T-lymphoid cell lines, but they do not stimulate B-lymphoblastoid or myeloid cell lines. The results therefore suggest that these LDGFs are T-cell specific.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Neoplasm / analysis
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Antigens, Surface / analysis
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Cell Cycle / drug effects
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Cell Line
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Dose-Response Relationship, Drug
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Growth Substances / biosynthesis*
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Humans
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Interleukin-2 / pharmacology
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Lymphoma / metabolism*
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Lymphoma / pathology
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Peptide Biosynthesis*
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Serum Albumin, Bovine / pharmacology
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism*
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Transforming Growth Factors
Substances
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Neoplasm
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Antigens, Surface
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Growth Substances
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Interleukin-2
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Serum Albumin, Bovine
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Transforming Growth Factors