Total Synthesis of Carthamin, a Traditional Natural Red Pigment

Angew Chem Int Ed Engl. 2019 Apr 8;58(16):5321-5326. doi: 10.1002/anie.201900454. Epub 2019 Mar 18.

Abstract

The first total synthesis of carthamin (3), a historic natural red pigment, has been achieved. The molecular structure was efficiently constructed by assembling two equivalents of the in situ generated lithiated monomers and triisopropyl orthoformate. This synthesis confirms the structure proposed in 1996.

Keywords: flavonoids; glycosides; natural products; structure elucidation; total synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Chalcone / analogs & derivatives*
  • Chalcone / chemical synthesis
  • Chalcone / chemistry
  • Glucosides / chemical synthesis*
  • Glucosides / chemistry
  • Molecular Structure
  • Pigments, Biological / chemical synthesis*
  • Pigments, Biological / chemistry

Substances

  • Biological Products
  • Glucosides
  • Pigments, Biological
  • Chalcone
  • carthamine