Predictive values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and other prognostic factors in pediatric idiopathic sudden sensorineural hearing loss

Ryun Ha; Byeoung Woo Lim; Dong Hyun Kim; Jung Woo Park; Chang Hyun Cho; Ju Hyoung Lee

doi:10.1016/j.ijporl.2019.02.023

Predictive values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and other prognostic factors in pediatric idiopathic sudden sensorineural hearing loss

Int J Pediatr Otorhinolaryngol. 2019 May:120:134-139. doi: 10.1016/j.ijporl.2019.02.023. Epub 2019 Feb 11.

Authors

Ryun Ha¹, Byeoung Woo Lim², Dong Hyun Kim³, Jung Woo Park⁴, Chang Hyun Cho⁵, Ju Hyoung Lee⁶

Affiliations

¹ Department of Otolaryngology, Head and Neck Surgery, Gil Medical Center, School of Medicine, Gachon University, Incheon, South Korea. Electronic address: scherzojj@naver.com.
² Department of Otolaryngology, Head and Neck Surgery, Gil Medical Center, School of Medicine, Gachon University, Incheon, South Korea. Electronic address: docguri@naver.com.
³ Department of Otolaryngology, Head and Neck Surgery, Gil Medical Center, School of Medicine, Gachon University, Incheon, South Korea. Electronic address: dongul@gilhospital.com.
⁴ Department of Otolaryngology, Head and Neck Surgery, Gil Medical Center, School of Medicine, Gachon University, Incheon, South Korea. Electronic address: dhrhdxorwk@gmail.com.
⁵ Department of Otolaryngology, Head and Neck Surgery, Gil Medical Center, School of Medicine, Gachon University, Incheon, South Korea. Electronic address: cho@gilhospital.com.
⁶ Department of Otolaryngology, Head and Neck Surgery, Gil Medical Center, School of Medicine, Gachon University, Incheon, South Korea. Electronic address: febent@gilhospital.com.

PMID: 30784810
DOI: 10.1016/j.ijporl.2019.02.023

Abstract

Background and objectives: No consensus has been reached regarding the optimum treatment or factors affecting prognosis in pediatric idiopathic sudden sensorineural hearing loss (ISSNHL) due to its rarity. In the present study, treatment outcomes and prognostic factors of ISSNHL were investigated in pediatric patients who underwent steroid therapy.

Subjects: and Methods: Forty-two patients diagnosed with ISSNHL were enrolled in this retrospective study and compared with 39 normal healthy controls with respect to demography and complete blood cell count test results. In addition, prognosis factors were sought by dividing the 42 ISSNHL patients to 3 groups according to their response to the treatment.

Results: Neutrophil-to-lymphocyte ratio (NLR) value in the ISSNHL group were significantly higher than in the control group. NLR value in the three treatment response groups differed significantly. Early treatment with steroid and accompanying tinnitus were positive prognostic factor for hearing recovery. Other characteristics were not significant.

Conclusion: The results of this study suggest that good hearing recovery in children may be associated with early time of initial treatment and accompanying tinnitus. Also, NLR value might be useful readily accessible prognostic markers in pediatric ISSNHL patients. Further studies are required to confirm prognostic factors useful to predict prognosis and treat ISSNHL in pediatric patients.

Keywords: Neutrophil to lymphocyte ratio (NLR); Pediatric idiopathic sudden sensorineural hearing loss; Platelet to lymphocyte ratio (PLR); Prognostic factors.

MeSH terms

Adolescent
Blood Platelets*
Child
Female
Hearing Loss, Sensorineural / blood*
Hearing Loss, Sensorineural / complications
Hearing Loss, Sensorineural / drug therapy*
Hearing Loss, Sudden / blood*
Hearing Loss, Sudden / complications
Hearing Loss, Sudden / drug therapy*
Humans
Lymphocyte Count
Lymphocytes*
Male
Neutrophils*
Platelet Count
Prognosis
Retrospective Studies
Steroids / therapeutic use*
Tinnitus / complications*
Treatment Outcome

Substances

Steroids