Kidney aging: an irresistible slope

Abstract

Kidney aging is a multifactorial process. Using genome-wide database analysis, Rowland et al. identified testis-specific Y-encoded-like protein 5 as a candidate age-related renal gene, and reported that with aging, testis-specific Y-encoded-like protein 5 expression decreases in response to increased testis-specific Y-encoded-like protein 5 promoter methylation. Genome-wide databases are readily available, and we should carefully analyze them to find a mechanism to fight kidney aging on the experiments using cells and animals, not just in silico calculations.