Zebrafish models for attention deficit hyperactivity disorder (ADHD)

Barbara D Fontana; Francini Franscescon; Denis B Rosemberg; William H J Norton; Allan V Kalueff; Matthew O Parker

doi:10.1016/j.neubiorev.2019.02.009

Zebrafish models for attention deficit hyperactivity disorder (ADHD)

Neurosci Biobehav Rev. 2019 May:100:9-18. doi: 10.1016/j.neubiorev.2019.02.009. Epub 2019 Feb 16.

Authors

Barbara D Fontana¹, Francini Franscescon², Denis B Rosemberg³, William H J Norton⁴, Allan V Kalueff⁵, Matthew O Parker⁶

Affiliations

¹ Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK. Electronic address: barbara.fontana@port.ac.uk.
² Graduate Program in Biological Sciences, Toxicological Biochemistry, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil.
³ Graduate Program in Biological Sciences, Toxicological Biochemistry, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA.
⁴ Department of Neuroscience, Psychology and Behaviour, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, LE1 7RH, UK; The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA.
⁵ School of Pharmacy, Southwest University, Chongqing, 400700, China; Institute of Translational Biomedicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, 199034, Russia; Neuropharmacology Laboratory, ZENEREI Research Center, Slidell, LA, 70458, USA; Laboratory of Biological Psychiatry, ITBM, St Petersburg State University, St Petersburg 199034, Russia; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk 630117, Russia; Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg 197758, Russia; Ural Federal University, Ekaterinburg, 620002, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA.
⁶ Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK; The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA. Electronic address: matthew.parker@ac.uk.

PMID: 30779935
DOI: 10.1016/j.neubiorev.2019.02.009

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing animal models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.

Keywords: ADHD; Behavior; Dopamine; Genetics; Noradrenaline; Serotonin; Zebrafish.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Attention Deficit Disorder with Hyperactivity / genetics*
Attention Deficit Disorder with Hyperactivity / physiopathology*
Behavior, Animal
Brain / physiopathology*
Disease Models, Animal*
Translational Research, Biomedical*
Zebrafish / genetics