Visualizing the vasculature of the entire human eye posterior hemisphere without a contrast agent

Biomed Opt Express. 2018 Dec 12;10(1):167-180. doi: 10.1364/BOE.10.000167. eCollection 2019 Jan 1.

Abstract

The platform described here combines the non-invasive measurement of the retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide-field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The combination of these two imaging modalities within the same platform enables comprehensive assessment of blood flow in the retina and choroid in animals and human subjects for diagnostic purposes. Ultra-widefield vasculature visualization is demonstrated here for the first time without injecting additional contrast agents and based only on the motion of particles within the vasculature.