Multiple autoimmune syndrome is a rare condition, defined by the association of at least three autoimmune disorders in the same patient, and first described by Humbert and Dupond in 1988. Psoriasis, vitiligo, and oral lichen planus are all common dermatological disorders in the general population, and the coexistence of these three diseases in these exact clinical variants has never been reported in the literature before. Herein, we describe an unusual case of co-occurrence of psoriasis vulgaris, vitiligo, and oral lichen planus. A 67-yearold Romanian female patient with a history of both vitiligo and psoriasis presented with white, shiny striae, organized in a reticular pattern on the mucosa of the cheek and whitish homogeneous irregularities similar to leukoplakia involving the dorsal side of the tongue. Histology examination confirmed oral lichen planus. The rarity of this case is highlighted by the coexistence of psoriasis, vitiligo, and oral lichen planus in the absence of cutaneous lichen planus lesions, an association which may be a newly described variant of multiple autoimmune syndrome.