Capnodynamic determination of cardiac output in hypoxia-induced pulmonary hypertension in pigs

Abstract

Background: Effective pulmonary blood flow (CO_EPBF) has recently been validated for its ability to measure cardiac output (CO) in children and animals. This study compared CO_EPBF with the Fick method (CO_Fick) and CO measurements using an invasive pulmonary artery flow probe (CO_TS). The aim of the study was to validate CO_EPBF against these reference methods in a porcine model of hypoxia-induced selective pulmonary hypertension.

Methods: Ten anaesthetised mechanically ventilated piglets (median weight 23.9 kg) were exposed to a hypoxic gas mixture inducing selective pulmonary hypertension. Pulmonary hypertension was subsequently reversed with inhaled nitric oxide. Simultaneous recordings of CO_EPBF, CO_Fick, and CO_TS were performed throughout the protocol and examined for agreement and trending ability.

Results: Overall bias (Bland-Altman) between CO_EPBF and CO_TS was 0.2 L min^-1 (limits of agreement -0.5 and +0.9 L min^-1) with a mean percentage error of 25%. Overall bias between CO_EPBF and CO_Fick was -0.1 L min^-1 (limits of agreement -0.9 and +0.6 L min^-1) and a mean percentage error of 25%. The concordance rate was 86% for CO_EPBF when compared with CO_TS using a 10% exclusion zone.

Conclusions: Estimation of CO with CO_EPBF results in values very close to the gold standard reference methods CO_Fick and CO_TS. CO_EPBF appears to be an accurate tool for monitoring absolute values and changes in CO during hypoxia-induced pulmonary hypertension and inhaled nitric oxide treatment.

Keywords: carbon dioxide; cardiac output; hypertension; inhaled nitric oxide; paediatric pulmonary hypertension; pulmonary; pulmonary blood flow.