Digital PCR in bone marrow trephine biopsies is highly sensitive for MYD88L265P detection in lymphomas with plasmacytic/plasmacytoid differentiation

Digital PCR in bone marrow trephine biopsies is highly sensitive for MYD88^L265P detection in lymphomas with plasmacytic/plasmacytoid differentiation

Br J Haematol. 2019 Jul;186(1):189-191. doi: 10.1111/bjh.15792. Epub 2019 Feb 14.

Ella Willenbacher¹, Wolfgang Willenbacher^{1

2}, Dominik G Wolf^{1

3}, Bettina Zelger⁴, Ines Peschel⁵, Claudia Manzl⁶, Margot Haun⁴, Andrea Brunner⁴

¹ Internal Medicine V. Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.
² Oncotyrol, Centre for Personalized Cancer Medicine, Innsbruck, Austria.
³ Medical Clinic 3, Oncology, Haematology, Rheumatology and Immunoncology, University Clinic Bonn (UKB), Bonn, Germany.
⁴ Institute of Pathology, Neuropathology and Molecular Pathology, Innsbruck Medical University, Innsbruck, Austria.
⁵ Institute for Medical and Chemical Laboratory Diagnostics, Medical University Innsbruck, Innsbruck, Austria.
⁶ Division of General Pathology, Department of Pathology, Innsbruck Medical University, Innsbruck, Austria.

No abstract available

Keywords: IgM paraproteinaemia; MYD88 mutation; Waldenström macroglobulinaemia; molecular diagnostics; polymerase chain reaction.