Association Between HLA Genotype and Cutaneous Adverse Reactions to Antiepileptic Drugs Among Epilepsy Patients in Northwest China

Xu Wang; Lina Chao; Xiaojing Liu; Xianrui Xu; Qing Zhang

doi:10.3389/fneur.2019.00001

Association Between HLA Genotype and Cutaneous Adverse Reactions to Antiepileptic Drugs Among Epilepsy Patients in Northwest China

Front Neurol. 2019 Jan 29:10:1. doi: 10.3389/fneur.2019.00001. eCollection 2019.

Authors

Xu Wang¹, Lina Chao², Xiaojing Liu³, Xianrui Xu¹, Qing Zhang^{1

4}

Affiliations

¹ Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
² Department of Neurology, The First People's Hospital, Shizuishan, China.
³ Department of Neurology, The First Hospital of Tongxiang, Tongxiang, China.
⁴ Ningxia Key Laboratory of Cerebrocranial Diseases, The Incubation Base of National Key Laboratory, Yinchuan, China.

Abstract

This study aimed to investigate the association between HLA genotypes and antiepileptic drug-induced cutaneous adverse reactions (AEDs-cADRs) among patients with epilepsy in Ningxia Hui Autonomous Region of Northwest China. Fifteen patients with AEDs-cADRs and 30 matched AEDs tolerant controls from anested case-control study were tested the HLA-A, HLA-B, and HLA-DRB1 genotype using the polymerase chain reaction sequence-based typing (PCR-SBT). Significant difference was not observed between AEDs-cADRs and AEDs tolerant groups in terms of HLA-A, HLA-B, and HLA-DRB1 genotype frequencies. Future studies using larger cohorts are needed to verify this observation.

Keywords: Chinese; HLA genotype; antiepileptic drugs; cutaneous adverse reaction; epilepsy.