Placental Neuropeptide Y ( NPY) and NPY receptors expressions and serum NPY levels in preeclampsia

Roongrit Klinjampa; Chantacha Sitticharoon; Xaynaly Souvannavong-Vilivong; Chanakarn Sripong; Issarawan Keadkraichaiwat; Malika Churintaraphan; Saimai Chatree; Tripop Lertbunnaphong

doi:10.1177/1535370219831437

Placental Neuropeptide Y ( NPY) and NPY receptors expressions and serum NPY levels in preeclampsia

Exp Biol Med (Maywood). 2019 Apr;244(5):380-388. doi: 10.1177/1535370219831437. Epub 2019 Feb 13.

Authors

Roongrit Klinjampa¹, Chantacha Sitticharoon¹, Xaynaly Souvannavong-Vilivong¹, Chanakarn Sripong¹, Issarawan Keadkraichaiwat¹, Malika Churintaraphan¹, Saimai Chatree¹, Tripop Lertbunnaphong²

Affiliations

¹ 1 Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
² 2 Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Abstract

Neuropeptide Y (NPY) has been reported as a vasoconstrictive substance which might be associated with preeclampsia. The novel findings of this study were that Y1R, Y2R, and Y5R expressions were significantly lower in the PE than the NP group. Moreover, the NPY receptor expression ratio between the PE/NP groups was lowest for Y2R (0.27) compared to Y1R (0.42) and Y5R (0.40) suggestive of a reduction of this receptor in the preeclampsia group. Our results suggested that decreased Y2R mRNA in the PE group might be associated with abnormalities of placental angiogenesis which probably contributes to the pathophysiology of preeclampsia.

Keywords: NPY receptors; Preeclampsia; blood pressure; gene expression; neuropeptide Y.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Neuropeptide Y / metabolism*
Placenta / metabolism*
Pre-Eclampsia / metabolism*
Pregnancy
Receptors, Neuropeptide Y / metabolism*

Substances

Neuropeptide Y
Receptors, Neuropeptide Y