Molecular and Nonmolecular Magnetic Resonance Coronary and Carotid Imaging

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):569-582. doi: 10.1161/ATVBAHA.118.311754.

Abstract

Atherosclerosis is the leading cause of cardiovascular morbidity and mortality. Over the past 2 decades, increasing research attention is converging on the early detection and monitoring of atherosclerotic plaque. Among several invasive and noninvasive imaging modalities, magnetic resonance imaging (MRI) is emerging as a promising option. Advantages include its versatility, excellent soft tissue contrast for plaque characterization and lack of ionizing radiation. In this review, we will explore the recent advances in multicontrast and multiparametric imaging sequences that are bringing the aspiration of simultaneous arterial lumen, vessel wall, and plaque characterization closer to clinical feasibility. We also discuss the latest advances in molecular magnetic resonance and multimodal atherosclerosis imaging.

Keywords: atherosclerosis; magnetic resonance angiography; molecular imaging; morbidity; mortality.

Publication types

  • Review

MeSH terms

  • Carotid Arteries / diagnostic imaging*
  • Carotid Artery Diseases / diagnostic imaging*
  • Carotid Artery Diseases / economics
  • Contrast Media
  • Coronary Angiography / methods*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / economics
  • Forecasting
  • Gadolinium
  • Humans
  • Magnetic Resonance Angiography / methods*
  • Metal Nanoparticles
  • Multimodal Imaging
  • Plaque, Atherosclerotic / chemistry
  • Plaque, Atherosclerotic / diagnostic imaging*
  • Plaque, Atherosclerotic / pathology
  • Positron Emission Tomography Computed Tomography
  • Positron-Emission Tomography

Substances

  • Contrast Media
  • Gadolinium