Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

MuhChyi Chai; Jun Kohyama

doi:10.1016/j.stemcr.2019.01.011

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Stem Cell Reports. 2019 Feb 12;12(2):183-185. doi: 10.1016/j.stemcr.2019.01.011.

Authors

MuhChyi Chai¹, Jun Kohyama²

Affiliations

¹ Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Keio University Global Research Institute (KGRI), Keio University, 2-15-45, Mita, Minato-ku, Tokyo 108-8345, Japan.
² Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: jkohyama@a7.keio.jp.

Abstract

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Astrocytes / metabolism*
Astrocytes / pathology*
Dopaminergic Neurons / pathology
Humans
Parkinson Disease / metabolism*
Parkinson Disease / pathology*
Stem Cells / metabolism
Stem Cells / pathology
alpha-Synuclein / metabolism*

Substances

alpha-Synuclein