Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

Yanet Parodis Lopez; Nery Sablon Gonzalez; Noel Lorenzo Villalba; Rafael Camacho Galvan; Jose Carlos Rodriguez Perez

doi:10.12890/2016_000446

Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

Eur J Case Rep Intern Med. 2016 Jul 20;3(5):000446. doi: 10.12890/2016_000446. eCollection 2016.

Authors

Yanet Parodis Lopez¹, Nery Sablon Gonzalez¹, Noel Lorenzo Villalba¹, Rafael Camacho Galvan¹, Jose Carlos Rodriguez Perez¹

Affiliation

¹ Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas, Spain.

Abstract

We report a case of a 64-year-old man who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anaemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease.

Learning points: Drug-induced TTP is a rare condition and difficult to diagnose.Decreased activity of ADAMTS13, unusual in drug-induced TTP, was present in this case.

Keywords: Thrombotic microangiopathy; prasugrel; thrombotic thrombocytopenic purpura.