Solvolysis Artifacts: Leucettazoles as Cryptic Macrocyclic Alkaloid Dimers from a Southern Australian Marine Sponge, Leucetta sp

Mar Drugs. 2019 Feb 9;17(2):106. doi: 10.3390/md17020106.

Abstract

Keywords: ethanolysis; solvolysis; artifact; leucettazoles; leucettazines; macrocyclic alkaloids; Leucetta; Australian sponge; GNPS.

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Australia
  • Cell Line, Tumor
  • Colorectal Neoplasms / drug therapy
  • Cytotoxins / chemistry
  • Cytotoxins / pharmacology
  • HEK293 Cells
  • Humans
  • Imidazoles / chemistry*
  • Imidazoles / pharmacology*
  • Macrocyclic Compounds / chemistry*
  • Macrocyclic Compounds / pharmacology*
  • Microbial Sensitivity Tests
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Cytotoxins
  • Imidazoles
  • Macrocyclic Compounds
  • leucettamine B