We Could Use More Tolerance: Role of Intestinal-Allograft-Derived Human Stem Cells

Norma Sue Kenyon

doi:10.1016/j.stem.2019.01.009

We Could Use More Tolerance: Role of Intestinal-Allograft-Derived Human Stem Cells

Cell Stem Cell. 2019 Feb 7;24(2):197-198. doi: 10.1016/j.stem.2019.01.009.

Author

Norma Sue Kenyon¹

Affiliation

¹ Diabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: nkenyon@med.miami.edu.

PMID: 30735643
DOI: 10.1016/j.stem.2019.01.009

Abstract

Mixed chimerism is associated with allograft acceptance and tolerance. In this issue of Cell Stem Cell, Fu et al. (2019) provide evidence that functional, donor-derived hematopoietic stem and progenitor cells in the intestinal allograft can persist long-term, contribute to multi-lineage chimerism in the circulation, and result in T cell tolerance through host lymphoid organ selection.

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MeSH terms

Allografts
Hematopoietic Stem Cell Transplantation*
Humans
Immune Tolerance*
Transplantation, Homologous