Animal Models of Breast Cancer Bone Metastasis

Claudia Tulotta; Arwin Groenewoud; B Ewa Snaar-Jagalska; Penelope Ottewell

doi:10.1007/978-1-4939-8997-3_17

Animal Models of Breast Cancer Bone Metastasis

Methods Mol Biol. 2019:1914:309-330. doi: 10.1007/978-1-4939-8997-3_17.

Authors

Claudia Tulotta¹, Arwin Groenewoud², B Ewa Snaar-Jagalska², Penelope Ottewell³

Affiliations

¹ Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.
² Institute of Biology, Leiden University, Leiden, The Netherlands.
³ Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK. p.d.ottewell@sheffield.ac.uk.

PMID: 30729473
DOI: 10.1007/978-1-4939-8997-3_17

Abstract

This chapter is designed to provide a comprehensive overview outlining the different in vivo models available for research into breast cancer bone metastasis. The main focus is to guide the researcher through the methodological processes required to establish and utilize these models within their own laboratory. These detailed methods are designed to enable the acquisition of accurate and meaningful results that can be used for publication and future translation into clinical benefit for women with breast cancer-induced bone metastasis.

Keywords: Bone metastasis; Breast cancer; Mouse; Zebrafish.

MeSH terms

Animals
Bone Neoplasms / diagnostic imaging
Bone Neoplasms / pathology
Bone Neoplasms / secondary*
Bone and Bones / diagnostic imaging
Bone and Bones / pathology
Breast Neoplasms / diagnostic imaging
Breast Neoplasms / pathology*
Cell Line, Tumor
Disease Models, Animal*
Embryo, Nonmammalian
Female
Humans
Luciferases / chemistry
Luminescent Measurements / instrumentation
Luminescent Measurements / methods
Mice
Mice, Nude
Mice, SCID
Optical Imaging / instrumentation
Optical Imaging / methods
Xenograft Model Antitumor Assays / instrumentation
Xenograft Model Antitumor Assays / methods*
Zebrafish

Substances

Luciferases