Host Control of Tumor Feeding: Autophagy Holds the Key

Anthony Venida; Rushika M Perera

doi:10.1016/j.cmet.2019.01.009

Host Control of Tumor Feeding: Autophagy Holds the Key

Cell Metab. 2019 Feb 5;29(2):236-238. doi: 10.1016/j.cmet.2019.01.009.

Authors

Anthony Venida¹, Rushika M Perera²

Affiliations

¹ Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
² Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: rushika.perera@ucsf.edu.

PMID: 30726755
DOI: 10.1016/j.cmet.2019.01.009

Abstract

Cancer cells are dependent on functional autophagy both within their cytoplasm and systemically in the host to maintain growth. How systemic autophagy directly contributes to tumor growth remains unclear. In a study published in Nature, Poillet-Perez et al. (2018) show that host autophagy helps to maintain the levels of circulating arginine that feed tumor growth.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Arginine
Autophagy*
Humans
Neoplasms*

Substances

Arginine

Grants and funding

DP2 CA216364/CA/NCI NIH HHS/United States