Influence of Hormones on Sjögren's Syndrome

Curr Pharm Des. 2018;24(35):4167-4176. doi: 10.2174/1381612824666181010153536.

Abstract

Sjögren's syndrome (SS) is an immune system oral disorder that is characterized generally by dry mouth and eyes. In this review, SS classification, presentation and pathogenesis are briefly discussed. Moreover, the epidemiology of SS regarding sex, age and association with other complications are also presented. This review also addresses the interactions between endocrine axes and SS, and the important findings up to regarding hormone treatment of this syndrome. The main hormones discussed in this review includes Adrenocorticotropic hormone (ACTH), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), Thyroid-stimulating hormone (TSH), and prolactin.

Keywords: Antiphospholipid syndrome; Sjögren's syndrome; dry eyes; hormones; hypothyroidisem; immune system..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenocorticotropic Hormone* / metabolism
  • Female
  • Follicle Stimulating Hormone* / metabolism
  • Humans
  • Luteinizing Hormone* / metabolism
  • Prolactin* / metabolism
  • Sjogren's Syndrome / immunology
  • Sjogren's Syndrome / metabolism*
  • Sjogren's Syndrome / therapy*
  • Thyrotropin* / metabolism

Substances

  • Adrenocorticotropic Hormone
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Thyrotropin