HIV encephalitis in a patient on antiretroviral therapy: a case report

Maria Hlebowicz; Miłosz Parczewski; Paweł Jakubowski

doi:10.1177/0956462418824905

HIV encephalitis in a patient on antiretroviral therapy: a case report

Int J STD AIDS. 2019 May;30(6):617-619. doi: 10.1177/0956462418824905. Epub 2019 Feb 5.

Authors

Maria Hlebowicz¹, Miłosz Parczewski², Paweł Jakubowski³

Affiliations

¹ 1 Department of Infectious Diseases, Medical University of Gdansk, Gdansk, Poland.
² 2 Department of Infectious, Tropical Diseases and Immune Deficiency, Pomeranian Medical University, Szczecin, Poland.
³ 3 Pomeranian Hospitals, Gdansk, Poland.

PMID: 30722753
DOI: 10.1177/0956462418824905

Abstract

We present the case of a 52-year-old man with human immunodeficiency virus (HIV) encephalitis resulting from cerebrospinal fluid (CSF) viral escape, to illustrate therapeutic challenges in patients with emergent CSF genotypic HIV drug resistance. This case report highlights the usefulness of CSF HIV-resistance testing to guide antiretroviral therapy and treatment optimizing decisions.

Keywords: Cerebrospinal fluid; drug resistance; genotyping; immune reconstitution inflammatory syndrome; viral escape.

Publication types

Case Reports

MeSH terms

AIDS Dementia Complex / drug therapy*
AIDS Dementia Complex / virology
Anti-HIV Agents / adverse effects
Anti-HIV Agents / therapeutic use*
Antiretroviral Therapy, Highly Active
Cerebrospinal Fluid / virology*
Drug Resistance, Viral
HIV Infections / complications
HIV Infections / drug therapy*
HIV Infections / virology
HIV-1 / drug effects
HIV-1 / genetics
HIV-1 / isolation & purification*
Humans
Male
Middle Aged
Plasma / virology*
RNA, Viral / blood
RNA, Viral / cerebrospinal fluid
Treatment Outcome
Viral Load / drug effects*

Substances

Anti-HIV Agents
RNA, Viral