CCGG deletion (rs201074739) in CD33 results in premature termination codon and complete loss of CD33 expression: another key variant with potential impact on response to CD33-directed agents

Leuk Lymphoma. 2019 Sep;60(9):2287-2290. doi: 10.1080/10428194.2019.1569232. Epub 2019 Feb 5.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Biopsy
  • Bone Marrow / pathology
  • Codon, Nonsense
  • Codon, Terminator / genetics
  • DNA Mutational Analysis
  • Drug Resistance, Neoplasm / genetics*
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / therapy*
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / therapy*
  • Sequence Deletion
  • Sialic Acid Binding Ig-like Lectin 3 / analysis
  • Sialic Acid Binding Ig-like Lectin 3 / antagonists & inhibitors
  • Sialic Acid Binding Ig-like Lectin 3 / genetics*
  • Sialic Acid Binding Ig-like Lectin 3 / metabolism

Substances

  • Antineoplastic Agents
  • CD33 protein, human
  • Codon, Nonsense
  • Codon, Terminator
  • Sialic Acid Binding Ig-like Lectin 3