Abstract
Versispiroketal A (1), an unprecedented 6/5/5/6 tetracyclic polyketide featuring a rarely encountered bridge-fused spiroketal skeleton, was isolated from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. The structure and absolute configuration of 1 were unequivocally determined by comprehensive spectroscopic analysis, single-crystal X-ray diffraction analysis and quantum chemical ECD calculations. Compound 1 showed weak cytotoxicity against four cancer cell lines. A plausible biosynthetic pathway for 1 was also postulated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Aspergillus / chemistry*
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Cell Line, Tumor
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Crystallography, X-Ray
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Furans / chemistry*
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Furans / isolation & purification
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Furans / pharmacology
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Humans
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Models, Molecular
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Porifera / microbiology*
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Spiro Compounds / chemistry*
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Spiro Compounds / isolation & purification
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Spiro Compounds / pharmacology
Substances
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Antineoplastic Agents
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Biological Products
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Furans
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Spiro Compounds
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spiroketal