Unsupervised feature extraction of anterior chamber OCT images for ordering and classification

Sci Rep. 2019 Feb 4;9(1):1157. doi: 10.1038/s41598-018-38136-8.

Abstract

We propose an image processing method for ordering anterior chamber optical coherence tomography (OCT) images in a fully unsupervised manner. The method consists of three steps: Firstly we preprocess the images (filtering the noise, aligning and normalizing the resolution); secondly, a distance measure between images is computed for every pair of images; thirdly we apply a machine learning algorithm that exploits the distance measure to order the images in a two-dimensional plane. The method is applied to a large (~1000) database of anterior chamber OCT images of healthy subjects and patients with angle-closure and the resulting unsupervised ordering and classification is validated by two ophthalmologists.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anterior Chamber / diagnostic imaging*
  • Anterior Chamber / pathology
  • Female
  • Glaucoma, Angle-Closure / diagnostic imaging*
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Machine Learning
  • Male
  • Tomography, Optical Coherence / methods*