The role of necroptosis in cancer: A double-edged sword?

Xia Qin; Dan Ma; Ye-Xiong Tan; Hong-Yang Wang; Zhenyu Cai

doi:10.1016/j.bbcan.2019.01.006

The role of necroptosis in cancer: A double-edged sword?

Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):259-266. doi: 10.1016/j.bbcan.2019.01.006. Epub 2019 Feb 1.

Authors

Xia Qin¹, Dan Ma², Ye-Xiong Tan³, Hong-Yang Wang⁴, Zhenyu Cai⁵

Affiliations

¹ National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
² Department of General Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing, China.
³ National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. Electronic address: yxtan1214@163.com.
⁴ National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. Electronic address: hywangk@vip.sina.com.
⁵ National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. Electronic address: drcaizhenyu@126.com.

PMID: 30716362
DOI: 10.1016/j.bbcan.2019.01.006

Abstract

Necroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a potential therapeutic strategy against cancer. Here, we will review the recent research progress of necroptosis in conferring anti- or pro-tumoral effects and its potential application in cancer therapy.

Keywords: Cancer; MLKL; Metastasis; Necroptosis; RIPK3.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Death / physiology*
Humans
Necrosis / pathology
Neoplasms / pathology*