The Scourge of Antibiotic-resistant Infections in Cystic Fibrosis

Erin P Price; Derek S Sarovich

doi:10.1016/j.tim.2019.01.003

The Scourge of Antibiotic-resistant Infections in Cystic Fibrosis

Trends Microbiol. 2019 Apr;27(4):289-291. doi: 10.1016/j.tim.2019.01.003. Epub 2019 Jan 29.

Authors

Erin P Price¹, Derek S Sarovich²

Affiliations

¹ GeneCology Research Centre, University of the Sunshine Coast, Sippy Downs, Queensland, Australia; Sunshine Coast Health Institute, University of the Sunshine Coast, Birtinya, Queensland, Australia. Electronic address: eprice@usc.edu.au.
² GeneCology Research Centre, University of the Sunshine Coast, Sippy Downs, Queensland, Australia; Sunshine Coast Health Institute, University of the Sunshine Coast, Birtinya, Queensland, Australia.

PMID: 30709708
DOI: 10.1016/j.tim.2019.01.003

Abstract

Bacterial infections are the primary cause of respiratory decline and mortality in cystic fibrosis (CF) patients. In a recent study, Diaz Caballero and colleagues [1] (PLoS Pathog. 2018;14:e1007453) catalogued the molecular adaptation of a decade-long Burkholderia multivorans infection in a Canadian CF patient, which evolved to become resistant towards multiple classes of antibiotics.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anti-Bacterial Agents
Burkholderia
Burkholderia Infections*
Canada
Cystic Fibrosis*
Drug Resistance, Bacterial / drug effects
Genome-Wide Association Study
Humans
Recombination, Genetic

Substances

Anti-Bacterial Agents

Supplementary concepts

Burkholderia multivorans