Deltamethrin Residues in Milk and Cheese of Lactating Goats (Capra hircus)

Raffaele Marrone; Abilasha Ramkumar; Giorgio Smaldone; Domenico Rufrano; Claudia Chirollo; Vincenzo Veneziano; Martin Danaher; Aniello Anastasio

doi:10.3390/molecules24030517

Deltamethrin Residues in Milk and Cheese of Lactating Goats (Capra hircus)

Molecules. 2019 Jan 31;24(3):517. doi: 10.3390/molecules24030517.

Authors

Raffaele Marrone¹, Abilasha Ramkumar², Giorgio Smaldone³, Domenico Rufrano⁴, Claudia Chirollo⁵, Vincenzo Veneziano⁶, Martin Danaher⁷, Aniello Anastasio⁸

Affiliations

¹ Department of Veterinary Medicine and Animal Production, University of Naples ''Federico II'' Via F. Delpino, 1-80137 Naples, Italy. raffaele.marrone@unina.it.
² Food Safety Department, Teagasc Food Research Centre Ashtown, Dublin 15, D15 DY05 Dublin 15, Ireland. abilasha.ramkumar@teagasc.ie.
³ Department of Veterinary Medicine and Animal Production, University of Naples ''Federico II'' Via F. Delpino, 1-80137 Naples, Italy. giorgio.smaldone@unina.it.
⁴ Research Unit for the Extensive Animal Husbandry, CRA ZOE, Muro Lucano (PZ), 85054 Muro Lucano, Italy. drufrano@tiscali.it.
⁵ Department of Veterinary Medicine and Animal Production, University of Naples ''Federico II'' Via F. Delpino, 1-80137 Naples, Italy. c.chirollo@gmail.com.
⁶ Department of Veterinary Medicine and Animal Production, University of Naples ''Federico II'' Via F. Delpino, 1-80137 Naples, Italy. vinvene@unina.it.
⁷ Food Safety Department, Teagasc Food Research Centre Ashtown, Dublin 15, D15 DY05 Dublin 15, Ireland. Martin.Danaher@teagasc.ie.
⁸ Department of Veterinary Medicine and Animal Production, University of Naples ''Federico II'' Via F. Delpino, 1-80137 Naples, Italy. anastasi@unina.it.

Abstract

The distribution of pyrethroid insecticide deltamethrin (DLM) in goat milk and cheese (caciotta) following pour-on administration at the sheep dosage (DLMS-10 mL/60 kg body weight) and double dosage (DLMD-20 mL/60 kg body weight) was studied. DLM concentrations were measured in milk collected from study animals (No.14) before treatment and at 2, 4, 8, 12, 16, 24, 30, 36, 48, 56, until 168 h (7 days) post treatment and in caciotta cheese at 12 and 24 h post treatment. At both dosages, the maximum level of DLM residues in goat milk and cheese was below the maximum residue limit (MRL) of 20 μg kg^-1 established for bovine milk (EU No 37/2010) at all time points. However, in terms of public health, higher DLM residues in cheese show that further specific studies should be performed on double dosage efficacy and pharmacokinetic and pharmacodynamics properties of ectoparasites in lactating goats.

Keywords: UHPLC-MS/MS; ectoparasites; pyrethroid; withdrawal period.

MeSH terms

Animals
Cheese / analysis*
Chromatography, High Pressure Liquid
Female
Goats*
Lactation*
Milk / chemistry*
Nitriles / analysis*
Nitriles / chemistry*
Pyrethrins / analysis*
Pyrethrins / chemistry*
Sensitivity and Specificity
Tandem Mass Spectrometry

Substances

Nitriles
Pyrethrins
decamethrin