Objective: To evaluate the feasibility, safety and clinical value of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration (ENUS-TNNA) in the diagnosis of submucosal nasopharyngeal carcinoma. Methods: Clinical data of 9 patients from Sichuan Cancer Hospital with submucosal nasopharyngeal carcinoma undergoing ENUS-TNNA between December 2013 and January 2018 were retrospectively analyzed. The feasibility and safety were analyed. All 9 patients were all males with a mean age of (49.2±10.9) years. Results: Needle puncture biopsies were successfully performed in all cases, and sufficient tissue sample for histopathological examination was obtained from each of the 9 patients. No major bleeding or persistent bleeding occurred during and after puncture procedures. There were 5 patients with undifferentiated nonkeratinizing carcinoma and 4 patients poorly differentiated carcinoma. Conclusion: ENUS-TNNA is a safe, feasible and effective technique to provide a diagnosis of submucosal growth type of nasopharyngeal neoplasms, which has some clinical value.
目的： 探讨鼻咽内超声实时引导经鼻咽针吸活检术（endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration，ENUS-TNNA）诊断黏膜下型鼻咽癌的可行性，安全性及临床应用价值。 方法： 回顾性分析2013年12月至2018年1月四川省肿瘤医院内镜中心采用ENUS-TNNA技术诊断的9例黏膜下型鼻咽癌患者的临床资料，分析其安全性及可行性。 结果： 9例患者均为男性，平均年龄（49.2±10.9）岁。全组病例均一次性穿刺成功，获得了足够的组织标本，穿刺过程术中、术后未发生大出血或持续性渗血。9例患者术后病理结果证实鼻咽未分化非角化性癌5例，鼻咽低分化非角化性癌4例。 结论： ENUS-TNNA在技术上安全可行，是诊断黏膜下型NPC的有效方法，具有一定的临床价值。.
Keywords: Biopsy, fine-needle; Bronchoscopy; Endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration; Nasopharyngeal neoplasms.