Renal denervation with a resistant arterial hypertension: the results of a five-year follow-up

Ter Arkh. 2018 Sep 20;90(9):88-91. doi: 10.26442/terarkh201890988-91.

Abstract

Aim: To evaluate the 5-year results of renal denervation (RDN) in patients with resistant arterial hypertension (AH).

Materials and methods: The study included 14 patients to whom, during the 2011-2013 period RDN has been completed. Before and after the intervention, office blood pressure, quality of life indicators according to the EQ-5D questionnaire, mass index bodies, indicators of kidney function were duly assessed.

Results: Five years after RDN, office BP decreased from 165/110 to 139/95 mm Hg. Art. (p<0.05), with the average number of of drugs decreased from 4.6 to 3.1. 12 months after the RDA, the quality of Life, based on the questionnaire EQ-5D has increased from 60 to 80 points, by the fifth year the indicator fell to 74 points. Body mass index during 5 years decreased from 33.8 ± 3.5 to 30.9 ± 3.0 kg/m2. Mean plasma creatinine initially and after 5 years remained within the normal range, the mean the GFR score after 5 years being decreased by 9.5 ml/min/1.73 m2.

Conclusion: RDN can be regarded as effective and safe method of additional treatment of patients with resistant hypertension.

Keywords: arterial hypertension; renal denervation; resistant arterial hypertension.

MeSH terms

  • Adult
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Blood Pressure Monitoring, Ambulatory / methods
  • Drug Resistance, Multiple*
  • Female
  • Humans
  • Hypertension* / diagnosis
  • Hypertension* / physiopathology
  • Hypertension* / psychology
  • Hypertension* / surgery
  • Kidney* / innervation
  • Kidney* / physiopathology
  • Male
  • Middle Aged
  • Outcome and Process Assessment, Health Care
  • Quality of Life*
  • Retrospective Studies
  • Russia
  • Surveys and Questionnaires
  • Sympathectomy / methods*

Substances

  • Antihypertensive Agents