Abstract
Two new glutarimide antibiotics, 9-methylstreptimidone 2-α-D-glucopyranoside (1), and hydroxyiso-9-methylstreptimidone (2), along with a known compound, 9-methylstreptimidone (3), have been isolated from the broth of Streptomyces sp. HS-NF-780. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. By modified Mosher's method and acid hydrolysis, the absolute configurations of compounds 1 and 2 were established. Compounds 1 and 2 exhibited moderate cytotoxic activity.
MeSH terms
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacokinetics*
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Cell Line, Tumor
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Cell Survival / drug effects
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Culture Media / chemistry
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Cytological Techniques
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Piperidones / chemistry
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Piperidones / isolation & purification*
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Piperidones / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Streptomyces / growth & development
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Streptomyces / metabolism*
Substances
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Antibiotics, Antineoplastic
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Culture Media
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Piperidones
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glutarimide