[Chemoradiotherapy in combination with local hyperthermia for patients with non-small cell lung cancer]

Vopr Onkol. 2016;62(6):822-826.
[Article in Russian]

Abstract

Short-term treatment outcomes for 15 patients with stage IB-III non-small cell lung cancer (NSCLC) were present- ed. The patients were treated with thermochemoradiothrapy (TCRT). Hyperfractionated radiation therapy at a total dose of 40 Gy (1.3 Gy/fraction, twice daily, 5 days per week) was given concurrently with 2 courses of chemotherapy with pa- clitaxel (175 mg/m², i.v, on day 1) and carboplatin (AUC 6, i.v, on day 1). Ten sessions of local hyperthermia were deliv- ered using the Celsius TCS electro-hyperthermia system. Local hyperthermia was administered twice a week, 2 hours before radiotherapy or immediately after administration of chemotherapeutic agents, for 45-60 min at 41-43 °C. The overall, histologically confirmed, response rate was 93% with 3 (20%) patients achieving a complete response and 11 (73.3%) with a partial response. Stable disease was seen in 1 case (6.7%). No disease progression was found. Chemoradiotherapy and local hyperthermia were well tolerated. Twelve (88%) patients underwent radical surgery (RO): 8 (66.7%) lobectomy and 4 (33.3%) pneumonectomy (TCRT as an option of preoperative treatment). There were no postoperative complications and deaths. Radiation therapy was continued up to the total dose of 60-66 Gy in 3 cases (inoperable patients), and the number of local hyperthermia sessions was increased to 12-14 (TCRT alone). During the follow-up period of 12-14 months, no evidence of disease progression was observed. A prelimi- nary analysis of data obtained indicate that TCRT for patients with NSCLC is well tolerated, results in tumor regression, expand the indications for surgical treatment and demonstrates the encouraging results.

MeSH terms

  • Carboplatin / administration & dosage
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Chemoradiotherapy*
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperthermia, Induced*
  • Lung Neoplasms / mortality
  • Lung Neoplasms / therapy*
  • Male
  • Middle Aged
  • Paclitaxel / administration & dosage
  • Survival Rate

Substances

  • Carboplatin
  • Paclitaxel