Nanoarchitecture Frameworks for Electrochemical miRNA Detection

Mostafa Kamal Masud; Muhammad Umer; Md Shahriar A Hossain; Yusuke Yamauchi; Nam-Trung Nguyen; Muhammad J A Shiddiky

doi:10.1016/j.tibs.2018.11.012

Nanoarchitecture Frameworks for Electrochemical miRNA Detection

Trends Biochem Sci. 2019 May;44(5):433-452. doi: 10.1016/j.tibs.2018.11.012. Epub 2019 Jan 24.

Authors

Mostafa Kamal Masud¹, Muhammad Umer², Md Shahriar A Hossain³, Yusuke Yamauchi⁴, Nam-Trung Nguyen², Muhammad J A Shiddiky⁵

Affiliations

¹ Queensland Micro- and Nanotechnology Centre (QMNC), Griffith University, Nathan Campus, QLD 4111, Australia; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.
² Queensland Micro- and Nanotechnology Centre (QMNC), Griffith University, Nathan Campus, QLD 4111, Australia.
³ Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia; School of Mechanical & Mining Engineering, Faculty of Engineering, Architecture and Information Technology (EAIT), The University of Queensland, Brisbane, QLD 4072, Australia.
⁴ Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia; School of Chemical Engineering, Faculty of Engineering, Architecture and Information Technology (EAIT), The University of Queensland, Brisbane, QLD 4072, Australia; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
⁵ Queensland Micro- and Nanotechnology Centre (QMNC), Griffith University, Nathan Campus, QLD 4111, Australia; School of Environment and Science, Griffith University, Nathan Campus, QLD 4111, Australia. Electronic address: m.shiddiky@griffith.edu.au.

PMID: 30686572
DOI: 10.1016/j.tibs.2018.11.012

Abstract

With revolutionary advances in next-generation sequencing, the human transcriptome has been comprehensively interrogated. These discoveries have highlighted the emerging functional and regulatory roles of a large fraction of RNAs suggesting the potential they might hold as stable and minimally invasive disease biomarkers. Although a plethora of molecular-biology- and biosensor-based RNA-detection strategies have been developed, clinical application of most of these is yet to be realized. Multifunctional nanomaterials coupled with sensitive and robust electrochemical readouts may prove useful in these applications. Here, we summarize the major contributions of engineered nanomaterials-based electrochemical biosensing strategies for the analysis of miRNAs. With special emphasis on nanostructure-based detection, this review also chronicles the needs and challenges of miRNA detection and provides a future perspective on the presented strategies.

Keywords: electrochemical miRNA sensor; miRNA; miRNA detection; nanoarchitecture; nanoparticles; nanotechnology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques*
Electrochemical Techniques*
Humans
MicroRNAs / analysis*
Nanostructures / chemistry*

Substances

MicroRNAs