Coagulopathy, cryoprecipitate and CRYOSTAT-2: realising the potential of a nationwide trauma system for a national clinical trial

M Marsden; J Benger; K Brohi; N Curry; C Foley; L Green; J Lucas; A Rossetto; S Stanworth; H Thomas; R Davenport; CRYOSTAT-2 investigators

doi:10.1016/j.bja.2018.10.055

Coagulopathy, cryoprecipitate and CRYOSTAT-2: realising the potential of a nationwide trauma system for a national clinical trial

Br J Anaesth. 2019 Feb;122(2):164-169. doi: 10.1016/j.bja.2018.10.055. Epub 2018 Nov 28.

Authors

M Marsden¹, J Benger², K Brohi³, N Curry⁴, C Foley⁵, L Green⁶, J Lucas⁵, A Rossetto³, S Stanworth⁷, H Thomas⁸, R Davenport³; CRYOSTAT-2 investigators

Collaborators

CRYOSTAT-2 investigators:
N Howes⁹, D Foukaneli⁹, K Philpott⁹, C Aylwin¹⁰, F Chowdhury¹⁰, P Moss¹¹, St Wiltshire¹¹, J Keep¹², B Umlauft¹², J Thornley¹³, M Karakantza¹³, G Hussain¹³, R Procter¹⁴, C Elliott¹⁴, J Shelton¹⁵, G Smithson¹⁵, A Sattout¹⁶, J Gorry¹⁶, K Challen¹⁷, A Noyon¹⁷, S Carley¹⁸, T Trimble¹⁸, D Horner¹⁹, L Baxter¹⁹, M Darwent²⁰, S Hemmatpour²⁰, S Kellett²¹, K Dowling²¹, R Kong²², J Coles²², J Kendall²³, T Wreford-Bush²³, T Kehoe²⁴, M Binney²⁴, A Mahmood²⁵, S Morton²⁵, G Lowe²⁵, C Leech²⁶, M Mushkbar²⁶, R Hall²⁷, J Graham²⁷, A Brooks²⁸, C Chang²⁸, W Townend²⁹, Ma Bryan²⁹, R Elshaw²⁹, J Squires³⁰, B Taylor³⁰, A Akhtar³¹

Affiliations

¹ Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, London, UK; Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, UK; Barts Health NHS Trust, London, UK. Electronic address: max.marsden@nhs.net.
² Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK.
³ Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, London, UK; Barts Health NHS Trust, London, UK.
⁴ Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Radcliffe Department of Medicine, University of Oxford, UK.
⁵ NHS Blood and Transplant, Clinical Trials Unit, Cambridge, UK.
⁶ Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK; Barts Health NHS Trust, London, UK.
⁷ Oxford NIHR BRC Haematology Theme, Oxford Centre for Haematology, University of Oxford, UK; NHS Blood and Transplant, Transfusion Medicine, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Radcliffe Department of Medicine, University of Oxford, UK.
⁸ NHS Blood and Transplant, Clinical Trials Unit, Bristol, UK; NHS Blood and Transplant, Transfusion Medicine, Oxford, UK.
⁹ Addenbrooke's Hospital, UK.
¹⁰ St. Mary's Hospital, UK.
¹¹ St. George's Hospital, UK.
¹² King's College Hospital, UK.
¹³ Leeds General Infirmary, UK.
¹⁴ James Cook University Hospital, UK.
¹⁵ Royal Victoria Infirmary, UK.
¹⁶ Aintree University Hospital, UK.
¹⁷ Royal Preston Hospital, UK.
¹⁸ Manchester Royal Infirmary, UK.
¹⁹ Salford Royal Hospital, UK.
²⁰ John Radcliffe Hospital, UK.
²¹ Southampton General Hospital, UK.
²² Royal Sussex County Hospital, UK.
²³ Southmead Hospital, UK.
²⁴ Derriford Hospital, UK.
²⁵ Queen Elizabeth Hospital, UK.
²⁶ Coventry University Hospital, UK.
²⁷ University Hospital of North Midlands, UK.
²⁸ Queen's Medical Centre, UK.
²⁹ Hull Royal Infirmary, UK.
³⁰ Northern General Hospital, UK.
³¹ Royal Victoria Hospital, UK.

PMID: 30686301
DOI: 10.1016/j.bja.2018.10.055

No abstract available

Publication types

Editorial

MeSH terms

Biomedical Research
Blood Coagulation Disorders / etiology*
Blood Coagulation Disorders / therapy*
Clinical Trials as Topic
Factor VIII / therapeutic use*
Fibrinogen / therapeutic use*
Hemorrhage / etiology*
Hemorrhage / therapy*
Humans
United Kingdom
Wounds and Injuries / complications
Wounds and Injuries / mortality
Wounds and Injuries / therapy*

Substances

cryoprecipitate coagulum
Factor VIII
Fibrinogen

Publication types

MeSH terms

Substances

Grants and funding