Clinical and Radiographic Features of Subtypes of Acute Proximal Junctional Failures Following Correction Surgery for Degenerative Sagittal Imbalance

World Neurosurg. 2019 May:125:e304-e312. doi: 10.1016/j.wneu.2019.01.069. Epub 2019 Jan 24.

Abstract

Objective: To identify clinical and radiographic features of subtypes of acute proximal junctional failures (PJFs) following correction surgery for degenerative sagittal imbalance.

Methods: The study included 157 patients with mean age 68.0 ± 6.3 years who underwent correction surgery for degenerative sagittal imbalance. Acute PJFs were categorized into 4 subtypes: fracture at uppermost instrumented vertebra (UIV), fracture at vertebra just proximal to UIV (UIV+1), fixation failure at UIV, and junctional subluxation. Demographic, clinical, and radiographic data were analyzed retrospectively.

Results: There were 18 patients with acute PJFs. PJF group had significantly lower T-score (-3.3 ± 1.1 vs. -1.9 ± 1.5) on bone densitometry and lower body mass index (BMI) (23.0 ± 3.9 kg/m2 vs. 25.6 ± 3.7 kg/m2) than non-PJF group. Radiographic parameters exhibited no significant differences. UIV fracture, UIV+1 fracture, UIV fixation failure, and junctional subluxation were observed in 5, 6, 4, and 3 patients. Fixation failure developed the earliest (median 1.3 months), followed by UIV fracture (1.5 months). UIV fracture occurred earlier than UIV+1 fracture (36 months). Patients with UIV or UIV+1 fracture had significantly lower T-scores than others. Although BMI and T-score were significant risk factors for all PJFs (P = 0.043 and P = 0.021, respectively), different risk factors for each subtype of PJFs were identified on separate risk factor analysis.

Conclusions: Patients with acute PJFs had lower T-score and BMI. Each subtype of PJFs had different clinical and radiographic features. Although BMI and T-score were associated with all PJFs, each subtype may have different risk factors. Identifying risk factors for each subtype of acute PJFs may help avoid it.

Keywords: Acute proximal junctional failure; Correction surgery; Degenerative; Risk factor; Sagittal imbalance; Subtype.

MeSH terms

  • Aged
  • Body Mass Index
  • Bone Density / physiology
  • Female
  • Humans
  • Kyphosis / diagnostic imaging
  • Kyphosis / surgery*
  • Lumbar Vertebrae / surgery
  • Male
  • Middle Aged
  • Postoperative Complications / diagnostic imaging
  • Postoperative Complications / etiology
  • Radiography
  • Reoperation
  • Retrospective Studies
  • Risk Factors
  • Spinal Fractures / diagnostic imaging
  • Spinal Fractures / etiology
  • Spinal Fractures / surgery
  • Spinal Fusion / adverse effects*
  • Treatment Failure