Cutaneous involvement as the first manifestation of T-lymphoblastic lymphoma and review of the literature

J Cutan Pathol. 2019 May;46(5):372-375. doi: 10.1111/cup.13431. Epub 2019 Mar 7.

Abstract

Lymphoblastic lymphomas (LBLs) are uncommon malignant neoplasms derived from immature T- or B-lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B-LBL, only 12 cutaneous cases of T-LBL have been published. We report the case of a 49-year-old woman with 2-month history of erythematous-violaceous plaques in the sternal region and breasts. Histopathologic examination showed a dense monomorphus infiltrate in dermis and positive immunostainings for CD3, CD99 and terminal deoxynucleotidyl transferase, thus indicating T-LBL. Staging work-up only revealed a mediastinal mass at diagnosis. After a 51-month follow-up and different treatment regimens, the patient remains alive although she has presented four relapses, all of them extramedullary.

Keywords: T-lymphoblastic lymphoma; cutaneous lymphoma; lymphoblastic lymphoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • 12E7 Antigen / metabolism*
  • Breast Neoplasms* / metabolism
  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / therapy
  • CD3 Complex / metabolism*
  • Dermis* / metabolism
  • Dermis* / pathology
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Proteins / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / therapy
  • Skin Neoplasms* / metabolism
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / therapy

Substances

  • 12E7 Antigen
  • CD3 Complex
  • CD99 protein, human
  • Neoplasm Proteins