Protracted course of disseminated adenovirus disease with necrotizing granulomas in the liver

Andrea M Lerner; John E Bennett; Stefania Pittaluga; Pavel P Khil; J H Youn; Gary A Fahle; Karen M Frank; John P Dekker; Theresa D Jerussi; Clare Sun; Adrian Wiestner; Juan Gea-Banacloche

doi:10.1016/j.diagmicrobio.2018.12.012

Protracted course of disseminated adenovirus disease with necrotizing granulomas in the liver

Diagn Microbiol Infect Dis. 2019 Jun;94(2):180-182. doi: 10.1016/j.diagmicrobio.2018.12.012. Epub 2019 Jan 2.

Authors

Affiliations

¹ Division of Clinical Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 9000 Center Drive, Bethesda, MD 20892, USA. Electronic address: andrea.lerner@nih.gov.
² Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Center Drive, Bethesda, MD 20892, USA.
³ Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), NIH, 9000 Center Drive, Bethesda, MD 20892, USA.
⁴ Microbiology Service, Department of Laboratory Medicine, NIH, 9000 Center Drive, Bethesda, MD 20892, USA.
⁵ Office of Patient Safety and Clinical Quality, Clinical Center, NIH, 9000 Center Drive, Bethesda, MD, 20892, USA.
⁶ Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, 9000 Center Drive, Bethesda, MD 20892, USA.
⁷ Division of Infectious Diseases, Mayo Clinic Hospital, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Abstract

A 52- year-old male with chronic lymphocytic leukemia was hospitalized with disseminated adenovirus disease. More than a month following recovery, hepatic necrotizing granulomas secondary to adenovirus were found. This case illustrates the protracted course that adenovirus disease may take and emphasizes an unusual presentation with hepatic necrotizing granulomas.

Keywords: Adenovirus; Liver; Necrotizing granuloma.

Published by Elsevier Inc.

Publication types

Case Reports

MeSH terms

Adenoviridae / isolation & purification*
Adenoviridae Infections / complications
Adenoviridae Infections / diagnosis*
Adenoviridae Infections / pathology*
Adenoviridae Infections / virology
Biopsy
Granuloma / diagnosis*
Granuloma / diagnostic imaging
Granuloma / pathology*
Granuloma / virology
Histocytochemistry
Humans
Immunohistochemistry
Leukemia, Lymphocytic, Chronic, B-Cell / complications
Liver Diseases / diagnosis*
Liver Diseases / diagnostic imaging
Liver Diseases / pathology*
Liver Diseases / virology
Male
Microscopy
Middle Aged
Necrosis / pathology
Radiography, Abdominal
Tomography, X-Ray Computed

Grants and funding

Z99 AI999999/ImNIH/Intramural NIH HHS/United States