In March 2017, a severely burned male patient aged 36 years with hypovolemic shock was admitted to our hospital. The patient received large quantities of antibiotics and blood products and repeated skin graft after admission, and then he suffered wound errhysis and throat congestion. The patient was healthy before without family history of bleeding or thrombosis disease. Laboratory tests showed that prothrombin time and activated partial coagulation time were remarkably prolonged, blood coagulation factor Ⅴ activity was extremely low, and the result of qualitative test of coagulation factor inhibitor was positive. Acquired blood coagulation factor Ⅴ deficiency was diagnosed. After application of dexamethasone (5 mg, twice per day) and infusion of fresh frozen plasma, blood coagulation indicators of patients recovered in 4 days, the result of qualitative test of coagulation factor inhibitor was negative, and bleeding symptoms were improved.
2017年3月，笔者单位收治1例严重烧伤伴低血容量性休克患者(男，36岁)，入院后，应用大量抗生素和血制品，同时多次进行植皮手术，之后患者出现创面渗血和咽喉部充血。患者既往体健，无出血或血栓性疾病家族史。实验室检查提示凝血酶原时间、活化部分凝血活酶时间显著延长，凝血因子Ⅴ活性极低，凝血因子抑制物定性试验结果阳性。诊断考虑获得性凝血因子Ⅴ缺陷症。应用地塞米松(5 mg，2次/d)，同时输注新鲜冰冻血浆，患者凝血功能指标在4 d内恢复正常，且凝血因子抑制物定性试验结果阴性，出血症状改善。.
Keywords: Blood coagulation factor inhibitor; Burns; Factor Ⅴ; Immunosuppressive therapy.