New criteria of burst suppression on electroencephalogram in dogs anesthetized with sevoflurane

Abstract

Burst suppression on electroencephalogram (EEG) is defined as suppression periods longer than 0.5 s during which the amplitude does not exceed 5 μV in human. The aims of this study were; 1) an attempt of creating new criteria of burst suppression in dogs; and 2) a survey on accuracy of sub-parameter of Bispectral index (BIS). Using a BIS monitor, suppression ratio (SR_BIS) and raw-EEG data were recorded at 2.0%, 2.5%, 3.0%, 3.5%, 4.0%, and 5.0% end-tidal sevoflurane concentration (ETSEV) in 6 beagle dogs. The minimum ETSEV at which burst suppression was visually confirmed (ETSEV_BS) was determined. By applying various duration and voltage threshold to criteria, suppression ratio was calculated (SR). Using the minimum balanced error rate (BER), new criteria consisting of the minimum duration of 0.35 s and the maximum threshold of 2.25 μV that provided SR > 0 above ETSEV_BS was screened. SR was set by these criteria (SR_BER) and by manual inspection (SR_TRUE). The median detection rate of SR_BER/SR_TRUE was a statistically significant increase (p < .01) compared to that of SR_BIS/SR_TRUE (77% and 17% at 3.5% ETSEV, 89% and 19% at 4.0% ETSEV, and 86% and 84% at 5.0% ETSEV, respectively). In addition, between SR_BER and SR_TRUE evaluated by regression and Bland-Altman analyses, there was a strong correlation (r = 0.967, p < .001) and a moderate agreement (Limits of agreement: -7.14 ± 13.95). The method using BER may help to establish new criteria of burst suppression to grasp the excessive deep level of anesthesia.

Keywords: BIS; Balanced error rate; Burst suppression; Dog; EEG; New criteria; SR; Suppression ratio.