Collision Tumor of Urothelial Cell Carcinoma and Clear Cell Renal Cell Carcinoma: A Case Report and Review of the Contemporary Literature

Appl Immunohistochem Mol Morphol. 2020 Oct;28(9):e82-e86. doi: 10.1097/PAI.0000000000000728.

Abstract

We present a case of synchronous renal cell carcinoma and urothelial carcinoma. Our case was a true collision tumor and both components were high grade. Metastasis to the adrenal gland by the urothelial carcinoma was observed. The morphologic impression was confirmed with GATA3 expression by the urothelial carcinoma component and PAX8 expression by the renal cell carcinoma component. We have reviewed the contemporary literature of this unusual dual diagnosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma, Clear Cell / diagnosis*
  • Aged, 80 and over
  • Carcinoma, Renal Cell / diagnosis*
  • Diagnosis, Differential
  • Female
  • GATA3 Transcription Factor / metabolism
  • Hematuria
  • Humans
  • Immunohistochemistry / methods*
  • Kidney Neoplasms / diagnosis*
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Neoplasms, Multiple Primary
  • PAX8 Transcription Factor / metabolism
  • Urothelium / pathology*

Substances

  • GATA3 Transcription Factor
  • GATA3 protein, human
  • PAX8 Transcription Factor
  • PAX8 protein, human