Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

J Neurovirol. 2019 Jun;25(3):410-414. doi: 10.1007/s13365-018-00719-6. Epub 2019 Jan 22.

Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

Keywords: Africa; Epidemiology; HIV; HIV-associated neurocognitive disorder; Vitamin D.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Dementia Complex* / blood
  • AIDS Dementia Complex* / cerebrospinal fluid
  • Adult
  • Female
  • Humans
  • Male
  • Uganda
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D / cerebrospinal fluid
  • Vitamin D-Binding Protein* / blood

Substances

  • Vitamin D-Binding Protein
  • Vitamin D
  • 25-hydroxyvitamin D