Acrepyrone A, a new γ-pyrone derivative from an endophytic fungus, Acremonium citrinum SS-g13

Nat Prod Res. 2020 Apr;34(8):1091-1096. doi: 10.1080/14786419.2018.1548462. Epub 2019 Jan 19.

Abstract

A new γ-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determined by analysing MS, NMR, and ECD data. Compound 1 was evaluated for its cytotoxic effect, antibacterial activity and quorum sensing inhibitory potential.

Keywords: Endophytes; bioactivities; natural products; γ-pyrone derivative.

MeSH terms

  • Acremonium / chemistry*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification
  • Cytotoxins / pharmacology
  • Endophytes / chemistry
  • Humans
  • Molecular Structure
  • Plant Roots / drug effects
  • Plants, Medicinal / microbiology*
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Quorum Sensing / drug effects

Substances

  • Anti-Bacterial Agents
  • Cytotoxins
  • Pyrones