The effects of a muscarinic receptor 1 gene variant on executive and non-executive cognition in schizophrenia spectrum disorders

Sean P Carruthers; Vanessa Cropley; Chad Bousman; Ian P Everall; Erica Neill; Christos Pantelis; Philip J Sumner; Eric J Tan; Australian Schizophrenia Research Bank; Kiymet Bozaoglu; Elizabeth H X Thomas; Tamsyn E Van Rheenen; Caroline T Gurvich; Susan L Rossell

doi:10.1016/j.psychres.2019.01.032

The effects of a muscarinic receptor 1 gene variant on executive and non-executive cognition in schizophrenia spectrum disorders

Psychiatry Res. 2019 Mar:273:178-180. doi: 10.1016/j.psychres.2019.01.032. Epub 2019 Jan 11.

Authors

Affiliations

¹ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia. Electronic address: scarruthers@swin.edu.au.
² Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia.
³ Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Cooperative Research Centre (CRC) for Mental Health, 161 Barry Street, Carlton, Victoria 3053, Australia; Departments of Medical Genetics, Psychiatry, and Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
⁴ Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Cooperative Research Centre (CRC) for Mental Health, 161 Barry Street, Carlton, Victoria 3053, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Centre for Neural Engineering, The University of Melbourne, Carlton, Victoria, Australia.
⁵ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia.
⁶ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Cooperative Research Centre (CRC) for Mental Health, 161 Barry Street, Carlton, Victoria 3053, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; Centre for Neural Engineering, The University of Melbourne, Carlton, Victoria, Australia.
⁷ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia.
⁸ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia; Psychiatry, St Vincent's Hospital, Melbourne, Victoria 3065, Australia.
⁹ Schizophrenia Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, New South Wales 2010, Australia.
¹⁰ Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria 3052, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria 3052, Australia.
¹¹ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
¹² Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
¹³ Monash Alfred Psychiatry research centre (MAPrc), Monash University Central Clinical School and The Alfred Hospital, Melbourne 3004 Australia.

PMID: 30654302
DOI: 10.1016/j.psychres.2019.01.032

Abstract

Individuals with schizophrenia who are homozygous at the c.267C > A (rs2067477) single nucleotide polymorphism within the muscarinic M1 receptor gene have been reported to perform less well on the Wisconsin Card Sorting Test (WCST). We investigated if rs2067477 genotype variation influenced WCST performance and non-executive cognition cross-diagnostically in a sample of 147 schizophrenia spectrum participants (SSD) and 294 healthy controls. We were unable to detect any significant differences in executive and non-executive cognitive performance across genotype. A broader genetic focus should be considered when investigating the association between the muscarinic system and cognition in SSD.

Keywords: Cognitive flexibility; Schizophrenia spectrum disorder; Wisconsin Card Sorting Test.

Publication types

Evaluation Study

MeSH terms

Adult
Case-Control Studies
Cognition / physiology*
Cognition Disorders / genetics
Executive Function / physiology*
Female
Genotype
Homozygote
Humans
Male
Middle Aged
Neuropsychological Tests
Polymorphism, Single Nucleotide
Receptor, Muscarinic M1 / genetics*
Schizophrenia / genetics*
Wisconsin Card Sorting Test
Young Adult

Substances

Receptor, Muscarinic M1