Coordination microparticle vaccines engineered from tumor cell templates

Chem Commun (Camb). 2019 Jan 31;55(11):1568-1571. doi: 10.1039/c8cc10004g.

Abstract

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Aluminum / chemistry*
  • Animals
  • Cancer Vaccines / chemistry
  • Cancer Vaccines / immunology*
  • Catechin / analogs & derivatives*
  • Catechin / chemistry
  • Cell Line, Tumor
  • Cell Survival
  • Clathrin / metabolism
  • Coordination Complexes / chemistry
  • Dendritic Cells / cytology*
  • Dendritic Cells / metabolism
  • Endocytosis
  • Mice
  • Microscopy, Confocal
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Neoplasms / therapy
  • Transplantation, Homologous

Substances

  • Cancer Vaccines
  • Clathrin
  • Coordination Complexes
  • Catechin
  • epigallocatechin gallate
  • Aluminum