Abstract
A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.
MeSH terms
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Actin Cytoskeleton / metabolism
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Aluminum / chemistry*
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Animals
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Cancer Vaccines / chemistry
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Cancer Vaccines / immunology*
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Catechin / analogs & derivatives*
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Catechin / chemistry
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Cell Line, Tumor
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Cell Survival
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Clathrin / metabolism
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Coordination Complexes / chemistry
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Dendritic Cells / cytology*
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Dendritic Cells / metabolism
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Endocytosis
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Mice
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Microscopy, Confocal
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Neoplasms / immunology
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Neoplasms / metabolism
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Neoplasms / therapy
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Transplantation, Homologous
Substances
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Cancer Vaccines
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Clathrin
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Coordination Complexes
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Catechin
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epigallocatechin gallate
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Aluminum