Abstract
Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without a notable release of pro-inflammatory cytokines. These natural and biocompatible platelet-derived nanovesicles have great potential as biomaterials for inflammation-free injectable hemostasis.
MeSH terms
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Animals
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Biocompatible Materials / administration & dosage
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Biocompatible Materials / chemistry
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Blood Platelets / cytology
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Blood Platelets / metabolism*
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Calcium Chloride / chemistry
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Cytokines / metabolism
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Hemorrhage / prevention & control
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Mice
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Nanostructures / administration & dosage
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Nanostructures / chemistry*
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Particle Size
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Platelet Glycoprotein GPIIb-IIIa Complex / metabolism
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Sonication
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Thrombin / chemistry
Substances
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Biocompatible Materials
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Cytokines
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Platelet Glycoprotein GPIIb-IIIa Complex
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Thrombin
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Calcium Chloride