Strategic design of a Mussel-inspired in situ reduced Ag/Au-Nanoparticle Coated Magnesium Alloy for enhanced viability, antibacterial property and decelerated corrosion rates for degradable implant Applications

Sci Rep. 2019 Jan 15;9(1):117. doi: 10.1038/s41598-018-36545-3.

Abstract

Magnesium (Mg) and its alloys have attracted much attention as a promising candidate for degradable implant applications however the rapid corrosion of magnesium inside the human body greatly limits its use as an implant material. Therefore, coating the alloy surface with a multifunctional film is a promising way to overcome the drawbacks. Here we propose for the first time a multifunction layer coating to enhance the cell viability, antibacterial property and decelerated corrosion rates to act as a novel material to be used for degradable implant Applications. For that, the magnesium alloy (AZ31) was first treated with hydrofluoric acid (HF) and then dopamine tris Hydrochloric acid (tris-HCL) solution. The reducing catechol groups in the polydopamine (PD) layer subsequently immobilize silver/gold ions in situ to form uniformly dispersed Ag/Au nanoparticles on the coating layer. The successful formation of Ag/Au nanoparticles on the HF-PD AZ31 alloy was confirmed using XPS and XRD, and the morphology of all the coated samples were investigated using SEM images. The alloy with HF-PDA exhibit enhanced cell attachment and proliferation. Moreover, the nanoparticle immobilized HF-PD alloy exhibited dramatic corrosion resistance enhancement with superior antibacterial properties and accountable biocompatibility. Thus the result suggest that HF-PD Ag/Au alloy has great potential in the application of degradable implant and the surface modification method is of great significance to determine its properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys / therapeutic use
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Cells, Cultured
  • Coated Materials, Biocompatible / pharmacology*
  • Corrosion
  • Gold / pharmacology*
  • Hydrofluoric Acid / pharmacology*
  • Indoles / pharmacology*
  • Materials Testing
  • Metal Nanoparticles
  • Polymers / pharmacology*
  • Prostheses and Implants
  • Silver / pharmacology*
  • Surface Properties

Substances

  • Alloys
  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Indoles
  • Mg-Al-Zn-Mn-Si-Cu alloy
  • Polymers
  • polydopamine
  • Silver
  • Gold
  • Hydrofluoric Acid