Aims: Recently, it was suggested that betatrophin has a role in controlling pancreatic β cell proliferation and lipid metabolism, however, its role in human subjects has not been established yet. The predicting role of betatrophin and MDA along with other biochemical indicators in type 2 diabetes mellitus (T2DM) in a sample of the Iraqi population was examined in the present investigation.
Methods: A total of 31 patients diagnosed with T2DM and 30 adult subjects without diabetes were matched in age and gender in a case-control study. Logistic and linear regression models were performed to examine the role of MDA and betatrophin in T2DM and triglyceride, respectively.
Results: The study confirmed a higher concentration of LDL (124.45 vs. 102.70 mg/dL; P = .001) and TG (191.13 vs. 103.83 mg/dL; P < .0001), insulin (18.40 vs. 10.97 μU/mL; P < .0001), and Hs. CRP (5.39 vs. 2.80 mg/L; P = .033) in diabetic patients compared to the controls. No significant difference in betatrophin and MDA was found between diabetic patients and non-diabetic healthy subjects. The study showed triglyceride as the only predictor of T2DM (P = .028). Similarly, total cholesterol (P < .0001), HDL (P = .001), LDL (P < .0003), and MDA (P = .010) were shown as predictors of triglyceride in diabetic patients.
Conclusion: The present study that triglyceride is a direct and MDA is an indirect predictor for T2DM.
Keywords: Circulating betatrophin; Inflammatory parameters; Metabolic parameters; Type 2 diabetes mellitus.
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