PFOS, PFOA, estrogen homeostasis, and birth size in Chinese infants

Abstract

Laboratory studies have suggested that perfluoroalkyl substances (PFASs) could affect fetal growth by disrupting estrogen homeostasis, but there are limited data for human. For this, 424 mother-infant pairs were selected from a cohort established in Hebei Province of North China in 2013. Two typical PFASs, perfluorooctyl sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), and three typical estrogens, estrone (E₁), β-estradiol (E₂), and estriol (E₃), were measured in cord serum. After adjusted for important covariates, serum PFOS was positively related to E₁ and E₃, but negatively related to E₂. Serum PFOA was positively related to serum E₁ and negatively related to head circumference at birth. Serum E₂ was negatively related to head circumference, body weight, and body length at birth and serum E₃ was positively related to body weight. Serum E₃ mediated the relationship between serum PFOS and body weight. There were sex-specific differences for the associations between PFOS/PFOA and estrogens/birth size. These findings suggested that exposure to PFASs could affect estrogen homeostasis and fetal growth during pregnancy and that estrogens might mediate the association between exposure to PFASs and fetal growth.

Keywords: Birth size; Chinese infants; Cord blood; Estrogens; Perfluoroalkyl substances.