Objective To observe the effects of Chinese drugs (CD) combined highly active an- tiretroviral therapy (HAART) on the prognosis of acquired immune deficiency syndrome (AIDS) patients. Methods From October 2012 to October 2014, 437 AIDS patients in the treatment base of AIDS prevention and control pilot project, Yunnan Institute of Traditional Chinese Medicine and Materia Medica, were as- signed to stage IIA blank group (refusal to any Chinese medical treatment or Western medical treatment), stage IIA CD group (refusal to HAART, and treated by Fuzheng Kangdu Pill/Kang'ai Baosheng Pill alone), stage IIB Western medicine (WM) group (receiving HAART alone), stage IIB CD combined WM group (re- ceiving Fuzheng Kangdu Pill/Kang'ai Baosheng Pill based on syndrome typing + HAART), stage ll WM group (the same treatment as stage IIB WM group) , and stage Ill CD combined WM group (the same treat- ment as stage IIB CD combined WM group). The therapeutic course for all was 24 months. The mortality and morbidity of AIDS patients were observed. Results (1) The percentages of stage IIA patients and stage IIB patients were in a gradually decreasing tendency in each group, while the percentages of stage III (onset) patients and dead patients were in a gradually increasing tendency after 12- and 24-month treat- ment. However, there was no statistical difference among them (P >0. 05). (2) As for stage IIA patients, as compared with stage II A blank group, stage IIA patients occupied a higher percentage, stage IIB, stage III (onset) , and dead patients occupied a lower percentage in IIA CD group, but with no statistical difference among them (P>0.05). (3) As for stage IIB patients, as compared with stage IIB WM groups, stage IIA and II B patients occupied a higher percentage, but with no statistical difference (P >0.05). But dead pa- tients in stage III (onset) occupied an obviously lowered percentage in the CD combined WM group (P < 0.05). (4) As for stage III patients (onset) , as compared with stage lIA WM groups, stage IIA and IIB pa- tients occupied a higher percentage, and dead patients in stage III (onset) occupied an obviously lowered percentage in the CD combined CM group, but with no statistical difference (P>0.05). Conclusions The morbidity and mortality of AIDS patients were in a gradually increasing tendency regardless of any treat- ment, or what kind of treatment. CD combined WM (Fuzheng Kangdu Pill/Kang'ai Baosheng Pill + HAART) could significantly lower the percentage of dead stage IIB patients.