Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Seyed Mohammadali Dadfar; Karolin Roemhild; Natascha I Drude; Saskia von Stillfried; Ruth Knüchel; Fabian Kiessling; Twan Lammers

doi:10.1016/j.addr.2019.01.005

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Adv Drug Deliv Rev. 2019 Jan 1:138:302-325. doi: 10.1016/j.addr.2019.01.005. Epub 2019 Jan 11.

Authors

Seyed Mohammadali Dadfar¹, Karolin Roemhild², Natascha I Drude³, Saskia von Stillfried⁴, Ruth Knüchel⁴, Fabian Kiessling¹, Twan Lammers⁵

Affiliations

¹ Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany.
² Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany; Institute of Pathology, Medical Faculty, RWTH Aachen University Clinic, Aachen, Germany.
³ Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany; Department of Nuclear Medicine, RWTH Aachen University Clinic, Aachen, Germany; Leibniz Institute for Interactive Materials - DWI, RWTH Aachen University, Aachen, Germany.
⁴ Institute of Pathology, Medical Faculty, RWTH Aachen University Clinic, Aachen, Germany.
⁵ Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany; Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands; Department of Targeted Therapeutics, University of Twente, Enschede, The Netherlands. Electronic address: tlammers@ukaachen.de.

Abstract

Many different iron oxide nanoparticles have been evaluated over the years, for a wide variety of biomedical applications. We here summarize the synthesis, surface functionalization and characterization of iron oxide nanoparticles, as well as their (pre-) clinical use in diagnostic, therapeutic and theranostic settings. Diagnostic applications include liver, lymph node, inflammation and vascular imaging, employing mostly magnetic resonance imaging but recently also magnetic particle imaging. Therapeutic applications encompass iron supplementation in anemia and advanced cancer treatments, such as modulation of macrophage polarization, magnetic fluid hyperthermia and magnetic drug targeting. Because of their properties, iron oxide nanoparticles are particularly useful for theranostic purposes. Examples of such setups, in which diagnosis and therapy are intimately combined and in which iron oxide nanoparticles are used, are image-guided drug delivery, image-guided and microbubble-mediated opening of the blood-brain barrier, and theranostic tissue engineering. Together, these directions highlight the versatility and the broad applicability of iron oxide nanoparticles, and indicate the integration in future medical practice of multiple iron oxide nanoparticle-based materials.

Keywords: MFH; MPI; MRI; Nanomedicine; SPION; Theranostics; USPIO.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Ferric Compounds* / chemistry
Ferric Compounds* / therapeutic use
Humans
Nanoparticles* / chemistry
Nanoparticles* / therapeutic use
Surface Properties
Theranostic Nanomedicine

Substances

Ferric Compounds
ferric oxide

Abstract

Publication types

MeSH terms

Substances

Grants and funding