Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

Guangshun Zhang; Junyuan Cao; Yan Cai; Yang Liu; Yanli Li; Peilin Wang; Jiao Guo; Xiaoying Jia; Mengmeng Zhang; Gengfu Xiao; Yu Guo; Wei Wang

doi:10.1007/s13238-018-0604-x

Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

Protein Cell. 2019 Feb;10(2):137-142. doi: 10.1007/s13238-018-0604-x.

Authors

Guangshun Zhang^{1

2

3

4}, Junyuan Cao^{1

5}, Yan Cai^{2

3

4}, Yang Liu¹, Yanli Li^{2

3

4}, Peilin Wang^{1

5}, Jiao Guo^{1

5}, Xiaoying Jia^{1

5}, Mengmeng Zhang^{1

2

3

4}, Gengfu Xiao^{1

5}, Yu Guo^{2

3

4}, Wei Wang^{6

7}

Affiliations

¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
² College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300450, China.
³ Drug Discovery Center for Infectious Disease, Nankai University, Tianjin, 300071, China.
⁴ Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, 300450, China.
⁵ University of the Chinese Academy of Sciences, Beijing, 100049, China.
⁶ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. wangwei@wh.iov.cn.
⁷ University of the Chinese Academy of Sciences, Beijing, 100049, China. wangwei@wh.iov.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Lassa virus / drug effects*
Lassa virus / physiology
Membrane Fusion / drug effects
Protein Domains
Structure-Activity Relationship
Viral Envelope Proteins / antagonists & inhibitors*
Viral Envelope Proteins / chemistry*
Viral Fusion Protein Inhibitors / chemistry
Viral Fusion Protein Inhibitors / pharmacology*

Substances

Viral Envelope Proteins
Viral Fusion Protein Inhibitors
glycoprotein gp2, lassa virus